Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

More Severe Seizure Patterns Favor Daytime

Epilepsia; ePub 2018 Apr 23; Goldenholz, et al

With the exception of status epilepticus (SE) in children, recent data indicate that more severe seizure patterns favor daytime. This suggests distinct day/night preferences for different seizure patterns in children and adults. Using approximations based on presumed US time zones, researchers characterized day and nighttime seizure patterns in a patient‐reported database, Seizure Tracker. A total of 632,995 seizures (n=9,698 patients) were classified into 4 categories: isolated seizure event (ISE), cluster without status epilepticus (CWOS), cluster including status epilepticus (CIS), and status epilepticus (SE). They found:

  • In adults, ISE was more likely at night compared to CWOS and to CIS.
  • The odds ratios (ORs) for ISE vs SE and CWOS vs SE were not significantly different regardless of cluster definition.
  • In children, ISE was less likely at night compared to SE.
  • ISE was more likely at night compared to CWOS and CIS.
  • CWOS was more likely during the night compared to CIS.

Citation:

Goldenholz DM, Rakesh K, Kapur K, et al. Different as night and day: Patterns of isolated seizures, clusters, and status epilepticus. [Published online ahead of print April 23, 2018]. Epilepsia. doi:10.1111/epi.14076.

This Week's Must Reads

Unilateral Thalamic Stimulation Improved Axial ET, Parkinsonism Relat Disord; ePub 2018 Sep 6; Mitchell, et al

Balance-Gait Disorder Risk Factor for Dementia in PD, J Parkinsons Dis; ePub 2018 Aug 13; Lichter, et al

Suicidal Ideation Prevalent in Persons with HD, J Huntingtons Dis; 2018 Jul 31; Wesson, et al

Everyday Functioning in Parkinson Disease Assessed, Parkinsonism Relat Disord; ePub 2018 Sep 1; Lopez, et al

Comparison of 2 DBS Methods for Essential Tremor, Mov Disord; ePub 2018 Sep 5; Fenoy, Schiess

Must Reads in Epilepsy & Seizures

Epilepsy Transition Care Gap in Young Adults, Epilepsy Behav; ePub 2018 Aug 25; Baca, et al

FDA Approves Diacomit for Treatment of Seizures, Biocodex news release; 2018 Aug 23

Depression, Suicidality Among People with Epilepsy, Epilepsy Behav; ePub 2018 Aug 13; Friedman, et al

Midlife Risk Factors Linked to Late-Onset Epilepsy, JAMA Neurology; ePub 2018 Jul 23; Johnson, et al

Nearly 1 Million Adults ≥55 Years Have Epilepsy, Epilepsy Behav; ePub 2018 Aug 2; Sapkota, et al