Women with epilepsy (WWE) seeking pregnancy without prior known infertility or related disorders have similar likelihood of achieving pregnancy, time to pregnancy, and live birth rates compared with their peers without epilepsy, a recent study found. The Women With Epilepsy: Pregnancy Outcomes and Deliveries study, an observational cohort study comparing fertility in WWE with fertility in control women (CW) without epilepsy, enrolled participants at 4 academic medical centers. They were observed up to 21 months from November 2010 to May 2015. Women seeking pregnancy, aged 18 to 40 years, were enrolled within 6 months of discontinuing contraception. Researchers found:
- Of the 197 women included in the study, 142 (72.1%) were white, and the mean (SD) age was 31.9 (3.5) years among the 89 WWE and 31.1 (4.2) among the 108 CW.
- Among 89 WWE, 54 (60.7%) achieved pregnancy vs 65 (60.2%) among 108 CW.
- Median time to pregnancy was no different between the groups after controlling for key covariates.
- 44 of 54 pregnancies (81.5%) in WWE and 53 of 65 pregnancies (81.5%) in CW resulted in live births.
Pennell PB, French JA, Harden CL, et al. Fertility and birth outcomes in women with epilepsy seeking pregnancy. [Published online ahead of print April 30, 2018]. JAMA Neurology. doi:10.1001/jamaneurol.2018.0646.
This Week's Must Reads
Quality of Life Varies in the Early Stages of MS, Disabil Health J; ePub 2018 May 31; Strober
Molecular Signature of EBV in MS Brain Lesions, Neurol Neuroimmunol Neuroinflamm; 2018 Jul; Moreno, et al
3D-FLAIR Detects Highest Infratentorial MS Lesions, Clin Imaging; 2018 Sep-Oct; Wang, Uribe, et al
Examining the Progression of Fatigue in MS, Mult Scler; 2018 Jun; van der Vuurst de Vries, et al
Psychosocial Adjustment in People with MS, Int J MS Care; 2018 May/Jun; Grech, et al
Must Reads in Epilepsy & Seizures
More Severe Seizure Patterns Favor Daytime, Epilepsia; ePub 2018 Apr 23; Goldenholz, et al
Epilepsy, Fertility, and Birth Outcomes Examined , JAMA Neurology; ePub 2018 Apr 30; Pennell, et al
FDA Approves Medtronic’s DBS Therapy for Epilepsy, Medtronic news release; 2018 May 1
Incidence of Periictal Apnea in Epileptic Seizures, Epilepsia; ePub 2018 Jan 16; Lacuey, Zonjy, et al
Epilepsy Seizure Rate and Education Level Linked, Epilepsy Behav; ePub 2017 Dec 24; Kumar, et al