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Depression, Suicidality Among People with Epilepsy

Epilepsy Behav; ePub 2018 Aug 13; Friedman, et al

Both depression and suicidal ideation are common among people with epilepsy (PWE) enrolled in self-management studies, according to a recent investigation. Researchers examined correlates of depressive symptoms and suicidal ideation in adults using pooled data from epilepsy self-management studies conducted by sites in the Centers for Disease Control and Prevention (CDC) Research Center's Managing Epilepsy Well (MEW) Network that assessed depression severity with the 9-item Patient Health Questionnaire (PHQ-9). They found:

  • Of the 770 subjects in the analysis (mean age 42.4 ± 13.0 years), the mean total PHQ-9 score was 9.4 ± 6.6 and 334 subjects (43.4%) had moderate to severe depressive symptoms (PHQ-9 ≥ 10).
  • Only ongoing seizures and low education were associated with moderate-severe depressive symptoms in multiple logistic regression analysis.
  • Suicidality (PHQ-9, item 9 score ≥ 1) was endorsed by 155 subjects (20.1%).
  • Only nonsuicidal depressive symptoms were associated with suicidality in multiple variable logistic regression analysis.

Citation:

Friedman D, Spruill TM, Liu H, et al. Depressive symptoms and suicidality among individuals with epilepsy enrolled in self-management studies: Results from the US Centers for Disease Control and Prevention Managing Epilepsy Well (MEW) Network. [Published online ahead of print August 13, 2018]. Epilepsy Behav. doi:10.1016/j.yebeh.2018.06.024.