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Vegetable/Fruit Intake Benefits Cognitive Function

Neurology; ePub 2018 Nov 21; Yuan, Fondell, et al

Recent findings support a long-term beneficial role of vegetable, fruit, and orange juice consumption on subjective cognitive function (SCF). Among 27,842 men with a mean age of 51 years in 1986, researchers used multinomial logistic regression to examine the relation of vegetable and fruit consumption to future SCF. Average dietary intake was calculated from 5 repeated food frequency questionnaires collected every 4 years until 2002. SCF score was assessed twice (2008 and 2012) using a 6-item questionnaire; validity was supported by strong associations with APO ε4 genotype. They categorized the average of the 2 scores as good, moderate, and poor SCF, and found:

  • Higher intakes of total vegetables, total fruits, and fruit juice were each significantly associated with lower odds of moderate or poor SCF after controlling for major non-dietary factors and total energy intake.
  • The association with total fruit intake was weaker after further adjusting for major dietary factors.
  • Higher consumption of vegetables and fruits 18 to 22 years before SCF assessment was associated with lower odds of poor SCF independent of more proximal intake.

Yuan C, Fondell E, Bhushan A, et al. Long-term intake of vegetables and fruits and subjective cognitive function in US men. [Published online ahead of print November 21, 2018]. Neurology. doi:10.1212/WNL.0000000000006684.