Increased Alzheimer disease (AD) risk was found for recent glaucoma diagnoses, established age-related macular degeneration (AMD) diagnoses, and both recent and established diabetic retinopathy (DR), according to a recent study. Therefore, people with certain ophthalmic conditions may have increased AD risk. Diagnoses of glaucoma, AMD, and DR were based on International Classification of Diseases, 9th revision, codes for 3,877 participants from the Adult Changes in Thought study. The adjusted hazard ratio (HR) for developing probable or possible AD for recent (within 5 years) and established (>5 years) diagnoses were assessed. Researchers found:
- In >31,142 person-years of follow-up, 792 AD cases occurred.
- The recent and established HR were 1.46 and 0.87 for glaucoma, 1.20 and 1.50 for AMD, and 1.50 and 1.50 for DR.
Lee CS, Larson EB, Gibbons LE, et al. Associations between recent and established ophthalmic conditions and risk of Alzheimer's disease. [Published online ahead of print August 8, 2018]. Alzheimers Dement. doi:10.1016/j.jalz.2018.06.2856.