Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Impact of Amyloid-Beta, Tau on Cognitive Decline

Ann Neurol; ePub 2018 Dec 14; Sperling, et al

Both amyloid‐beta (Aβ) and tau are necessary for memory decline in the preclinical stages of Alzheimer disease (AD), according to a recent study. These findings may be relevant for disambiguating aging and early cognitive manifestations of AD, and to inform secondary prevention trials in preclinical AD. 137 older individuals (age=76.3±6.22 years) participating in the Harvard Aging Brain Study underwent Aβ (11C‐Pittsburgh Compound B) and tau (18F‐Flortaucipir) positron emission tomography (PET) with prospective neuropsychological assessments following PET imaging. Tau and Aβ PET measures were assessed in regions of interest (ROI) as well as vertex‐wise map analyses. Cognitive change was evaluated with Memory and Executive Function composites. Researchers found:

  • Higher levels of Aβ and tau were both associated with greater memory decline, but not with change in executive function.
  • A significant interaction between tau and Aβ was observed in both ROI and map level analyses, such that rapid prospective memory decline was observed in participants who had high levels of both pathologies.
Citation:

Sperling RA, Mormino EC, Schultz AP, et al. The impact of Aβ and tau on prospective cognitive decline in older individuals. [Published online ahead of print December 14, 2018]. Ann Neurol. doi:10.1002/ana.25395.

This Week's Must Reads

Examining Brain Markers for Late-Onset Epilepsy, Neurology; ePub 2019 Jan 25; Johnson, et al

Hearing Loss Linked Cognitive Decline Risk in Men, Alzheimers Dement; ePub 2019 Jan 29; Curhan, et al

Brain Cholesterol Metabolism and PD Examined, Mov Disord; ePub 2019 Jan 25; Huang, et al

Sleep Behavior Disorder, Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2019 Jan 29; Duarte Folle, et al

Spontaneous Subarachnoid Hemorrhage During Pregnancy, J Stroke Cerebrovasc Dis; ePub 2019 Jan 30; Limaye, et al

Must Reads in Alzheimer's & Cognition

Hearing Loss Linked Cognitive Decline Risk in Men, Alzheimers Dement; ePub 2019 Jan 29; Curhan, et al

Aerobic Exercise Can Improve Executive Functioning , Neurology; 2019 Jan 15; Blumenthal, et al

Episodic Memory Decline is Neurodegenerative Marker, Neurology; ePub 2019 Jan 23; Wilson, Yang, et al

Cognitive Decline in Elderly Post-Hospitalization, Neurology; ePub 2019 Jan 11; James, Wilson, et al

Female Veterans, Military-Related Risk, and Dementia, Neurology; ePub 2018 Dec 12; Yaffe, et al