Clinical Edge | Clinical Neurology News

Seminal, highly anticipated Alzheimer’s trial falters

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Private equity firms acquiring more physician group practices,

Tramadol use for noncancer pain linked with increased hip fracture risk,

Antiepileptic Drugs May Not Independently Impair Cognition,

Thrombectomy Access Lags for U.S. Stroke Patients,

Functional Outcomes of SLAH May be Superior to Those of Open Resection,

FDA Actions

FDA Approves Firdapse for Rare Autoimmune Disorder, FDA news release; 2018 Nov 28

FDA Approves Ajovy for Migraine in Adults, Teva Pharmaceutical news release; 2018 Sep 14

Read more in FDA Actions

Clinical Guidelines

DBS Guidelines for Treatment of Patients with PD, Neurosurgery; ePub 2018 Mar 12; Rughani, et al

Guidelines for Reducing Brain Injury Post-Resuscitation, Neurology; ePub 2017 May 10; Geocardin, et al

Read more in Clinical Guidelines

Parkinson's Disease

Palliative Care Improves QoL for Patients With Parkinson’s Disease and Related Disorders,

Pimavanserin Reduced Dementia-Related Psychotic Symptoms Without Affecting Cognition,

Read more in Parkinson's Disease

Pediatrics

Pharmacologic prophylaxis fails in pediatric migraine,

EEG Abnormalities May Indicate Increased Risk for Epilepsy in Patients With Autism,

Read more in Pediatrics

Rare Diseases

Expedited Review Programs Not Shortening Drug Development,

Study Delineates Spectrum of Dravet Syndrome Phenotypes,

Read more in Rare Diseases

Movement Disorders

Palliative Care Improves QoL for Patients With Parkinson’s Disease and Related Disorders,

Synaptic Pruning Deficits May Cause Tremor in Essential Tremor,

Read more in Movement Disorders

Mixed Topics

Rate of Suicide is Higher in People With Neurologic Disorders,

Women With Epilepsy Less Likely Than Controls to Breastfeed,

Read more in Mixed Topics

Traumatic Brain Injury

Genetic Factor Linked to Impaired Memory After Heading Many Soccer Balls,

Delayed Clinical Care After Concussion May Prolong Recovery,

Read more in Traumatic Brain Injury

Trauma

Sensory Feedback May Smooth Walking With a Prosthetic Leg,

Posttraumatic Headache may be Associated With Reduced Pain Thresholds,

Read more in Trauma

Neurosurgery & Trauma

Hyperphosphorylated Tau Visible in TBI Survivors Decades After Brain Injury,

Researchers examine potential causes of dementia in CTE,

Read more in Neurosurgery & Trauma

GBS/CIDP

Guillain-Barré, Zika Virus, and Morbidity, JAMA Neurology; ePub 2018 May 21; Dirlikov, et al

Read more in GBS/CIDP

Headache & Migraine

Pharmacologic prophylaxis fails in pediatric migraine,

Dependent Trait in Chronic Migraine May Predict Nonresponse to Onabotulinumtoxin A,

Read more in Headache & Migraine

Business of Medicine

Private equity firms acquiring more physician group practices,

Physician Groups Push Back on Medicaid Block Grant Plan,

Read more in Business of Medicine

Stroke

Thrombectomy Access Lags for U.S. Stroke Patients,

BP levels during endovascular stroke therapy affect neurologic outcomes,

Read more in Stroke

Neuro-oncology

QoL Good for MGMT-Methylated Glioblastoma Patients With Lomustine-Temozolide,

Tandem Transplants Provide EFS Edge in Pediatric Neuroblastoma,

Read more in Neuro-oncology

Pain

Tramadol use for noncancer pain linked with increased hip fracture risk,

Migraine Comorbidities Rise With Increased Headache Days,

Read more in Pain

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