Progesterone luteal phase support can be valuable for women undergoing ovulation induction with gonadotropins in intrauterine insemination cycles, according to a meta-analysis of 11 trials involving nearly 3,000 individuals.
Participants underwent ovulation induction for infertility, followed by exogenous P luteal support. Investigators looked at pregnancy and live births. Among the results:
- Participants underwent a cumulative total of more than 4,000 cycles.
- In those receiving gonadotropins for ovulation induction, P-supplemented patients were 56% more likely to become pregnant; they were 77% more likely to have a live birth.
- These findings were also seen in an analysis of live births per intrauterineinsemination cycle.
- P support produced no pregnancy benefit in those who underwent ovulation induction with clomiphene with or without gonadotropins.
The authors noted that their analysis indicated that 11 patients need to be treated to have 1 additional live birth.
Green K, Zolton J, Schermerhorn S, et al. Progesterone luteal support after ovulation induction and intrauterine insemination: An updated systematic review and meta-analysis. [Published online ahead of print February 24, 2017]. Fertil Steril. doi:10.1016/j.fertnstert.2017.01.011.
This Week's Must Reads
Daily Steps Activity Linked with Weight Loss, Obesity; ePub 2018 Apr 6; Creasy, Lang, et al
Influence of Diabetes on Cardiovascular Events, Diabetes Care; ePub 2018 Apr 4; Newman, et al
T2D, Renal Cell Carcinoma Risk Linked in Women, Diabetes Care; ePub 2018 Apr 20; Graff, et al
A1C and Foot Ulcer Healing: No Meaningful Link, Diabetes Care; ePub 2018 April 6; Fesseha, et al
Diabetes Management and Decline in Depression, Diabetes Care; ePub 2018 Mar 27; Oh, Ell
Must Reads in Reproductive Endocrinology
This Can Quickly Assess Fertility Knowledge, Fertil Steril; ePub 2017 Sep 11; Kudesia, et al
Impact of Oral Contraceptives, Weight Loss on HDL, LDL, Clin Endocrinol; ePub 2017 Mar 9; Dokras, et al
Progesterone After Ovulation Induction and Insemination, Fertil Steril; ePub 2017 Feb 24; Green, et al
Sex Steroid Hormones and Fracture Risk in Older Women, J Clin Endocrinol Metab; ePub 2017 Jan 25; Cauley, et al
Thyroid Hormone Treatment’s Impact on Pregnancy Loss , BMJ; ePub 2017 Jan 25; Maraka, Mwangi, et al