Clinical Edge

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Progesterone After Ovulation Induction and Insemination

Fertil Steril; ePub 2017 Feb 24; Green, et al

Progesterone luteal phase support can be valuable for women undergoing ovulation induction with gonadotropins in intrauterine insemination cycles, according to a meta-analysis of 11 trials involving nearly 3,000 individuals.

Participants underwent ovulation induction for infertility, followed by exogenous P luteal support. Investigators looked at pregnancy and live births. Among the results:

  • Participants underwent a cumulative total of more than 4,000 cycles.
  • In those receiving gonadotropins for ovulation induction, P-supplemented patients were 56% more likely to become pregnant; they were 77% more likely to have a live birth.
  • These findings were also seen in an analysis of live births per intrauterineinsemination cycle.
  • P support produced no pregnancy benefit in those who underwent ovulation induction with clomiphene with or without gonadotropins.

The authors noted that their analysis indicated that 11 patients need to be treated to have 1 additional live birth.


Green K, Zolton J, Schermerhorn S, et al. Progesterone luteal support after ovulation induction and intrauterine insemination: An updated systematic review and meta-analysis. [Published online ahead of print February 24, 2017]. Fertil Steril. doi:10.1016/j.fertnstert.2017.01.011.

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