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Fat Deposition in Mexican Americans Assessed

Obesity; ePub 2017 Nov 27; Gao, Langefeld, et al

A genome-wide association study involving nearly 1,000 Mexican Americans showed that 6 loci were significantly linked with fat deposition and interactive effects. Participants were from the Insulin Resistance Atherosclerosis Family Study. Investigators analyzed nearly 7.8 million single-nucleotide polymorphisms (SNPs), looking at subcutaneous adipose tissue, visceral adipose tissue (VAT), and visceral-subcutaneous ratio (VSR). Among the results:

  • The strongest signal identified was SNP rs2185405 with VAT.
  • SNP rs12657394 was linked with VAT in males.
  • Male carriers of this variant had 24.6 cm2 increased VAT compared with noncarriers.
  • SNP rs10913233 in PAPPA2 and rs10923724 upstream of TBX15 were strongly linked with the interaction effect for VSR.

The authors noted that the results provide genetic evidence for a differential basis of fat deposition between genders.


Gao C, Langefeld C, Zeigler J, et al. Genome-wide study of subcutaneous and visceral adipose tissue reveals novel sex-specific adiposity loci in Mexican Americans. [Published online ahead of print November 27, 2017]. Obesity. doi:10.1002/oby.22074.

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