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Evaluating Metabolic Syndrome in Obese Adolescents

Metab Syndr Relat Disord; ePub 2017 Nov 20; Alemzadeh, et al

It is appropriate to use conventional lipoproteins to evaluate the presence of systemic inflammation, metabolic syndrome, and risk of atherosclerosis in adolescents with obesity, according to a study involving 143 individuals. This runs counter to the approach with adults, where using apolipoprotein measures are advantageous. Investigators looked at body mass index z-score, body composition, fasting glucose (FG), insulin, lipids, high-sensitive c-reactive protein (hs-CRP), HbA1C, and insulin resistance (IR) in adolescents with obesity. Among the results:

  • 55% of patients met diagnostic criteria for metabolic syndrome (MS) and displayed higher systolic blood pressure (SBP), BMI, fat mass, IR, hs-CRP, TG, TC/HDL, TG/HDL, ApoB/ApoA-1 ratio, and HbA1C than those without MS.
  • They had lower HDL and ApoA-1.
  • Overall, TC/HDL and ApoB/ApoA-1 ratios were strongly correlated.
  • ApoB/ApoA-1 and TC/HDL-C ratios were positively correlated with SBP.
  • ApoB/ApoA-1 and TC/HDL-C ratios were correlated with hs-CRP.

Citation:

Alemzadeh R, Kichler J. Comparison of apolipoprotein (ApoB/ApoA-1) and lipoprotein (total cholesterol/HDL) ratios in obese adolescents. [Published online ahead of print November 20, 2017]. Metab Syndr Relat Disord. doi:10.1089/met.2017.0135.

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