Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Avoiding Surgery for Low-Risk Thyroid Cancer

Thyroid; ePub 2017 Jan 26; Griffin, Brito, et al

Increasing the size threshold for active surveillance of papillary thyroid carcinoma (PTC) to 1.5 cm would allow more patients with low-risk cancer to be considered for this less aggressive approach, thus avoiding potential complications, according to an analysis involving nearly 700 individuals.

Participants had thyroid cancer and underwent thyroid surgery between 2003 and 2012. A decision-making framework for active surveillance was retrospectively applied to those whose nodules were ≤1.5 cm.

243 patients had PTC diagnosed based on FNA histology of Bethesda V or VI in thyroid nodules. Among them, 6% had nodules measuring ≤1 cm size, whereas nearly one-fourth had nodules measuring ≤1.5 cm. In the latter group:

  • 52 underwent total thyroidectomy and 4 had lobectomy.
  • 45 patients had elective central nodal dissection.
  • 14 had nodal metastases on pathology (all <4 mm).
  • 3 had permanent complications from surgery.


Griffin A, Brito J, Bahl M, Hoang J. Applying criteria of active surveillance to low-risk thyroid papillary cancer over a decade: How many surgeries and complications can be avoided? [Published online ahead of print January 26, 2017]. Thyroid. doi:10.1089/thy.2016.0568.

This Week's Must Reads

Anthropometric Measures as Diabetes Risk Factors, Diabetes Care; ePub 2018 Oct 23; Luo, Hendryx, et al

Comorbid Autoimmune Disease and Type 1 Diabetes, J Diabetes; ePub 2018 Sep 18; Bao, Weide, et al

QOL Assessed in Young Adults with Type 1 Diabetes, Diabetes Educ; ePub 2018 Oct 20; Kent, Quinn

Male Characteristics and Semen Parameters on IVF, Fertil Steril; 2018 Oct; Capelouto, Nagy, et al

Racial/Ethnic Differences in Glycemic Control in T1D, JAMA; ePub 2018 Sep 7; Kahkoska, Shay, et al

Must Reads in Endocrine Cancer

T2D, Renal Cell Carcinoma Risk Linked in Women, Diabetes Care; ePub 2018 Apr 20; Graff, et al

Weight-Loss Efforts in Endometrial Ca Survivors, Cochrane; 2018 Feb 1; Kitson, Ryan, et al

Can Estrogen Exposure Inhibit PNET Growth?, Clin Endocrinol; ePub 2017 Apr 6; Qiu, Christakis, et al

Avoiding Surgery for Low-Risk Thyroid Cancer , Thyroid; ePub 2017 Jan 26; Griffin, Brito, et al

Frequency of PD-NETs in Patients with Endocrine Tumors, Clin Endocrinol; ePub 2016 Nov 17; Donegan, et al