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Obesity Progression and Incident Diabetes Examined

Diabetes Care; ePub 2018 Mar 5; Stokes, Collins, et al

Findings from a recent study underscore the importance of population-level approaches to the prevention and treatment of obesity across the life course of individuals. Using data from the National Health and Nutrition Examination Survey (NHANES), researchers investigated the association between self-reported weight change from young adulthood to midlife and incident diabetes. They categorized individuals into 4 weight-change groups: those who remained non-obese (stable non-obese), those who moved from an obese BMI to a non-obese BMI (losing), those who moved from a non-obese BMI to an obese BMI (gaining), and those who remained obese (stable obese). Diabetes status was determined by self-report of a prior diagnosis, and age at diagnosis was used to establish time of diabetes onset. They found:

  • Those who were obese and lost weight exhibited a significantly lower risk of diabetes compared with those with stable obesity.
  • There was a lower risk among those who were stable non-obese and those in the gaining category.
  • There was also evidence of an increased incidence of diabetes among obese individuals who lost weight compared with individuals who were stable non-obese; however, weight loss was rare, and the association was not statistically significant.
Citation:

Stokes A, Collins JM, Grant BF, et al. Obesity progression between young adulthood and midlife and incident diabetes: A retrospective cohort study of US adults. [Published online ahead of print March 5, 2018]. Diabetes Care. doi:10.2337/dc17-2336.

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