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Mortality Is Rising in These People with Diabetes

Diabetes Care; ePub 2018, Feb 7; Kramer, et al

While albumin-to-creatinine ratios (ACR) are falling in US adults with diabetes, mortality rates are rising in those with low estimated glomerular filtration rate (eGFR) and lower ACR, according to a recent analysis. Participants were from NHANES 1988–2006 and had diabetes. Investigators looked at mortality trends by chronic kidney disease phenotype, specifically eGFR and ACR levels. Among the results:

  • Adults with an eGFR <60 mL/min/1.73 m2 and an ACR <30 mg/g represented 7% of the total population with diabetes during 1988–1994.
  • This rose to 10% of the diabetes population during 2007-2010.
  • Mortality rate trended down in those with diabetes and ACR ≥30 mg/g.
  • In those with eGFR <60 mL/min/1.73 m2, and ACR <30 mg/g, mortality rate increased from 35 to 51 deaths/1,000 person-years between the time periods.
Citation:

Kramer H, Boucher R, Leehey D, et al. Increasing mortality in adults with diabetes and low estimated glomerular filtration rate in the absence of albuminuria. [Published online ahead of print February 7, 2018]. Diabetes Care. doi:10.2337/dc17-1954.

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