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MetS Severity Z Score Helps Track T2D Treatment

Diabetes Care; ePub 2018 Oct 1; DeBoer, et al

Changes in risk indicators of metabolic syndrome (MetS) severity during intervention in the Diabetes Prevention Program (DPP) reflect altered disease risk and may help in tracking earlier responses to treatment and in motivating patients. This according to a recent study that assessed whether changes in MetS severity during the treatment of prediabetes are associated with reduced risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Researchers analyzed data for 2,476 adults with prediabetes in 1996–1999 randomized to receive treatment with lifestyle modification, medication, or placebo for 2–3 years and followed through 2014 for T2DM and CVD outcomes. They found:

  • Baseline MetS severity z score (MetS-Z) and its components were associated with risk of incident T2DM and CVD.
  • During year 1 of intervention, MetS-Z and its components decreased most with lifestyle modification, followed by treatment with medication and placebo.
  • Risk of T2DM within 1–5 years was most strongly associated with 1-year changes in MetS-Z and waist circumference (both HRs for a 1 SD increase = 1.80), whereas the risk of CVD was associated with a 1-year change in MetS-Z, glucose, and systolic blood pressure.
Citation:

DeBoer MD, Filipp SL, Gurka MJ. Use of a metabolic syndrome severity Z score to track risk during treatment of prediabetes: An analysis of the Diabetes Prevention Program. [Published online ahead of print October 1, 2018]. Diabetes Care. doi:10.2337/dc18-1079.

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