Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Markers of Bone Turnover, Diabetes Examined

Diabetes Care; ePub 2018 Jul 12; Massera, et al

In late postmenopausal women, levels of lower osteocalcin (OC), a marker of bone formation, and C-telopeptide of type 1 collagen (CTX), a marker of bone resorption, were associated with similarly increased risks of insulin resistance (HOMA-IR) at baseline and incident diabetes over long-term follow-up. This according to a recent study that sought to investigate the relationship between OC and CTX with incident diabetes in older women. The analysis included 1,455 female participants from the population-based Cardiovascular Health Study (mean [SD] age 74.6 [5.0] years). Researchers found:

  • OC and CTX were strongly correlated (r=0.80).
  • In cross-sectional analyses, significant or near-significant inverse associations with HOMA-IR were observed for continuous levels of OC (β=−0.12 per SD increment) and CTX (β=−0.08 per SD) after full adjustment for demographic, lifestyle, and clinical covariates.
  • During a median follow-up of 11.5 years, 196 cases of incident diabetes occurred.
  • After full adjustment, both biomarkers exhibited inverse associations with incident diabetes, associations that were comparable in magnitude and approached or achieved statistical significance.

Citation:

Massera D, Biggs ML, Walker MD, et al. Biochemical markers of bone turnover and risk of incident diabetes in older women: The Cardiovascular Health Study. [Published online ahead of print July 12, 2018]. Diabetes Care. doi:10.2337/dc18-0849.

This Week's Must Reads

Racial/Ethnic Differences in Glycemic Control in T1D, JAMA; ePub 2018 Sep 7; Kahkoska, Shay, et al

Youth Fasting Glucose and Midlife Cognitive Function, Diabetes Care; 2018 Oct; Bancks, Carnethon, et al

Prolactin Concentration Linked with Lower T2D Risk, Diabetologia; ePub 2018 Oct 11; Li, Rice, et al

Hypothalamic Obesity Treatment Strategies Explored, Obesity; ePub 2018 Oct 8; Rose, Horne, et al

MetS Severity Z Score Helps Track T2D Treatment , Diabetes Care; ePub 2018 Oct 1; DeBoer, et al

Must Reads in Diabetes

Racial/Ethnic Differences in Glycemic Control in T1D, JAMA; ePub 2018 Sep 7; Kahkoska, Shay, et al

Youth Fasting Glucose and Midlife Cognitive Function, Diabetes Care; 2018 Oct; Bancks, Carnethon, et al

Prolactin Concentration Linked with Lower T2D Risk, Diabetologia; ePub 2018 Oct 11; Li, Rice, et al

MetS Severity Z Score Helps Track T2D Treatment , Diabetes Care; ePub 2018 Oct 1; DeBoer, et al

Are T1D and Hearing Impairment Associated? , Diabetes Care; ePub 2018 Sep 25; Schade, et al