Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Influence of Diabetes on Cardiovascular Events

Diabetes Care; ePub 2018 Apr 4; Newman, et al

In a recent analysis of >10.5 million non-cardiac surgeries from a large US hospital admission database, perioperative major adverse cardiovascular and cerebrovascular events (MACCEs) were more common among patients with diabetes mellitus (DM) vs without DM. Perioperative MACCEs increased over time and individual end points were all less favorable for patients with DM. Patients aged ≥45 years who underwent non-cardiac surgery from January 2004 to December 2013 were identified using the US National Inpatient Sample. Perioperative MACCEs (in-hospital all-cause mortality, acute myocardial infarction, or acute ischemic stroke) by DM status were evaluated over time. Researchers found:

  • The final study sample consisted of 10,581,621 hospitalizations for major non-cardiac surgery; DM was present in ∼23% of surgeries and increased over time.
  • Patients with DM experienced MACCEs in 3.3% of surgeries vs 2.8% of surgeries for patients without DM.
  • From 2004 to 2013, the odds of perioperative MACCEs after multivariable adjustment increased by 6% for DM patients, compared with an 8% decrease for patients without DM.
  • Trends for individual end points were all less favorable for patients with DM vs those without DM.
Citation:

Newman JD, Wilcox T, Smilowitz NR, Berger JS. Influence of diabetes on trends in perioperative cardiovascular events. [Published online ahead of print April 4, 2018]. Diabetes Care. doi:10.2337/dc17-2046.

This Week's Must Reads

MetS Severity Z Score Helps Track T2D Treatment , Diabetes Care; ePub 2018 Oct 1; DeBoer, et al

Are T1D and Hearing Impairment Associated? , Diabetes Care; ePub 2018 Sep 25; Schade, et al

Look AHEAD Lifestyle Intervention Proves Effective, Obesity; 2018 Oct; Krukowski, Hare, et al

FDA Approves Xyosted for Testosterone Replacement, Antares Pharma news release; 2018 Oct 1

Glycemic Control, Dementia Risk in Type 1 Diabetes, Diabetes Care; ePub 2018 Sep 4; Lacy, Gilsanz, et al

Must Reads in Diabetes

MetS Severity Z Score Helps Track T2D Treatment , Diabetes Care; ePub 2018 Oct 1; DeBoer, et al

Are T1D and Hearing Impairment Associated? , Diabetes Care; ePub 2018 Sep 25; Schade, et al

Look AHEAD Lifestyle Intervention Proves Effective, Obesity; 2018 Oct; Krukowski, Hare, et al

Glycemic Control, Dementia Risk in Type 1 Diabetes, Diabetes Care; ePub 2018 Sep 4; Lacy, Gilsanz, et al

Diabetes, Coronary Artery Calcium in Subpopulations, Diab Vasc Dis Res; ePub 2018 Aug 16; Mamudu, et al