Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

A1C and Foot Ulcer Healing: No Meaningful Link

Diabetes Care; ePub 2018 April 6; Fesseha, et al

There does not appear to be a clinically meaningful association between baseline or prospective A1C and wound healing in patients with diabetic foot ulcers (DFUs), a recent study found. Researchers conducted a retrospective analysis of an ongoing prospective, clinic-based study of patients with DFUs treated at an academic institution during a 4.7-year period. Data from 270 participants and 584 wounds were included in the analysis. They found:

  • Baseline A1C was not associated with wound healing in univariate or fully adjusted models.
  • Compared with a nadir A1C change from baseline of −0.29 to 0.0 (tertile 2), a nadir A1C change of 0.09 to 2.4 (tertile 3) was positively associated with long-term wound healing in the subset of participants with baseline A1C <7.5%, but no association with wound healing was seen with the mean A1C change from baseline in this group.
  • Neither nadir A1C change nor mean A1C change were associated with long-term wound healing in participants with baseline A1C ≥7.5%.
Citation:

Fesseha BK, Abularrage CJ, Hines KF, et al. Association of hemoglobin A1c and wound healing in diabetic foot ulcers. [Published online ahead of print April 16, 2018]. Diabetes Care. doi:10.2337/dc17-1683.

This Week's Must Reads

LB Women Develop T2D Younger Than Hetero Women, Diabetes Care; ePub 2018 May 2; Corliss, et al

BMI Trajectories from Birth to Young Adulthood, Obesity; ePub 2018 Apr 19; McGinty, et al

Meat Cooking Methods and Type 2 Diabetes Risk, Diabetes Care; 2018 May; Liu, Zong, et al

Gestational Diabetes and Renal Function Examined, Diabetes Care; ePub 2018 May 4; Rawal, et al

Daily Steps Activity Linked with Weight Loss, Obesity; ePub 2018 Apr 6; Creasy, Lang, et al

Must Reads in Diabetes

LB Women Develop T2D Younger Than Hetero Women, Diabetes Care; ePub 2018 May 2; Corliss, et al

Meat Cooking Methods and Type 2 Diabetes Risk, Diabetes Care; 2018 May; Liu, Zong, et al

Gestational Diabetes and Renal Function Examined, Diabetes Care; ePub 2018 May 4; Rawal, et al

Influence of Diabetes on Cardiovascular Events, Diabetes Care; ePub 2018 Apr 4; Newman, et al

T2D, Renal Cell Carcinoma Risk Linked in Women, Diabetes Care; ePub 2018 Apr 20; Graff, et al