Clinical Edge

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PRAGMA-CF Shows Disease Progression of Cystic Fibrosis in Children

Key clinical point: A CT scoring system that primarily relies on the %disease can predict future airway disease in preschool children with cystic fibrosis.

Major finding: Each 1% increase in PRAGMA during preschool was associated with a 1.18% increase in bronchiectasis at school age.

Disclosures: Ms. Bouma had no financial disclosures.


Bouma NR et al. Pediatr Pulmonol. 2019 Sep 9 doi: 10.1002/ppul.24498; Rosenow et al. Am J Respir Crit Care Med. 2015 May 15. doi: 10.1164/rccm.201501-0061OC.