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Antenatal corticosteroids may increase risk for mental and behavioral disorders

Key clinical point: Exposure to maternal antenatal corticosteroid treatment is significantly associated with mental and behavioral disorders in children, compared with nonexposure.

Major finding: After adjustment for such variables as maternal age, smoking during pregnancy, any lifetime mental disorder diagnosis, and gestational age at birth, exposure to maternal antenatal corticosteroid treatment was significantly associated with mental and behavioral disorders in children, compared with nonexposure (HR, 1.33). Among children born at term, the adjusted HR was 1.47.

Study details: A population-based retrospective cohort study that included 670,097 children in Finland.

Disclosures: The study was funded by the Academy of Finland, European Commission, Foundation for Pediatric Research, the Signe and Ane Gyllenberg Foundation, the Novo Nordisk Foundation, the Sigrid Juselius Foundation, and the Juho Vainio Foundation. The authors had no conflict of interest disclosures.

Citation:

Räikkönen K et al. JAMA. 2020;323(19):1924-33. doi: 10.1001/jama.2020.3937.