Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Quitting smoking just 2 years before lung cancer diagnosis may improve survival

Key clinical point: Quitting smoking prior to a lung cancer diagnosis is associated with a significant survival benefit, even among patients who recently stopped smoking.

Major finding: The risk of death from any cause was cut by 12% for lung cancer patients who quit smoking up to 2 years before diagnosis, 16% for patients who quit 2-5 years before diagnosis, and 20% for those who quit more than 5 years before diagnosis.

Study details: A pooled analysis of 35,481 patients with lung cancer enrolled in 17 studies conducted by the International Lung Cancer Consortium.

Disclosures: The studies had multiple supporters. Dr. Fares reported no relevant disclosures, but one researcher disclosed relationships with AbbVie, AstraZeneca, MedImmune, Bayer, Bristol-Myers Squibb, Merck, Novartis, Pfizer, Roche Canada, and Takeda.


Fares AF et al. ASCO 2020, Abstract 1512.