Clinical Edge

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Metformin-TKI Combo Improves PFS in EGFR-Mutated Lung Cancer

Key clinical point: Adding metformin to EGFR-TKI therapy improved progression-free survival in patients with advanced lung adenocarcinoma.

Major finding: Median PFS was 13.1 months with metformin-EGFR-TKI combination therapy and 9.9 months with EGFR-TKI monotherapy (hazard ratio, 0.60; P = .03).

Study details: A phase 2 study of 139 patients with EGFR-mutated lung adenocarcinoma.

Disclosures: The study was funded by the National Council for Science and Technology in Mexico. The authors reported financial affiliations with AbbVie, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Lilly, Merck, Pfizer, Roche, and several others.


Arrieta O et al. JAMA Oncol. 2019 Sep 5. doi: 10.1001/jamaoncol.2019.2553.