Key clinical point: The measles virus changes the genetic diversity of naive and memory B cells, which leads to immunosuppression and a potential increase of secondary infections.
Major finding: B memory cells in measles patients showed increases in mutational frequency (P = .0008) and a reduction in CDR3 length (P = .017) of IGHV genes.
Study details: A study of genetic changes in the B-cell receptors of 26 unvaccinated children after measles.
Disclosures: The study was funded by grants to the investigators from the Indonesian Endowment Fund for Education, the Wellcome Trust, the German Centre for Infection Research, the Collaborative Research Centre of the German Research Foundation, the German Ministry of Health, and the Royal Society. The authors declared no conflicts of interest. Dr. Wesemann reported receiving support from National Institutes of Health grants and an award from the Burroughs Wellcome Fund; he also reported being a consultant for OpenBiome.
Petrova VN et al. Sci Immunol. 2019 Nov 1. doi: 10.1126/sciimmunol.aay6125; Wesemann DR Sci Immunol. 2019 Nov 1. doi: 10.1126/sciimmunol.aaz4195.