Key clinical point: Pediatric invasive pneumococcal disease in children could signal underlying primary immunodeficiency.
Major finding: Frequency of primary immunodeficiency in children with invasive pneumococcal disease ranged from 1% to 26%.
Study details: A systematic review of 17 studies involving 6,002 children with primary invasive pneumococcal disease.
Disclosures: No funding or conflicts of interest were declared for the study.
Butters C et al. JAMA Pediatr. 2019 Sep 30. doi: 10.1001/jamapediatrics.2019.3203.