Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

IPD in children may be a signal of immunodeficiency

Key clinical point: Pediatric invasive pneumococcal disease in children could signal underlying primary immunodeficiency.

Major finding: Frequency of primary immunodeficiency in children with invasive pneumococcal disease ranged from 1% to 26%.

Study details: A systematic review of 17 studies involving 6,002 children with primary invasive pneumococcal disease.

Disclosures: No funding or conflicts of interest were declared for the study.


Butters C et al. JAMA Pediatr. 2019 Sep 30. doi: 10.1001/jamapediatrics.2019.3203.