Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Opioid use disorder up in sepsis hospitalizations

Key clinical point: The prevalence of opioid use disorder (OUD) is significantly increased among patients hospitalized for sepsis over the 2009-2015 time period. Sepsis prevalence was higher among hospitalized patients with OUD.

Major finding: Prevalence of OUD among those hospitalized for sepsis increased by about 77% from 2009 to 2015. Prevalence of sepsis was 7.2% and 5.6%, respectively, for those with and without OUD (P less than .001).

Study details: Retrospective study of electronic health record data for adults admitted to 373 hospitals in the United States between 2009 and 2015, including 375,479 who had sepsis.

Disclosures: Dr. Alrawashdeh reported no disclosures related to the study.


Alrawashdeh M et al. Crit Care Med. 2020 Jan;48(1):28. Abstract 56.