Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Subtypes Offer Insight Into High Risk in COPD

Key clinical point: Subtypes can identify high-risk groups among current and former smokers in chronic obstructive pulmonary disease (COPD).

Major finding: Patients with COPD in the highest 2 deciles of the airway-predominant and/or emphysema-predominant axis had higher levels of mortality ranging from 21%-54%.

Study details: Analysis of 2,638 patients with COPD who made up the highest two deciles of the axes in a COPDGene cohort of 8,157 subjects.

Disclosures: The National Heart, Lung, and Blood Institute provided support for COPDGene and this study. COPDGene is also supported by the COPD Foundation through contributions to an industry advisory board (AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Novartis, Pfizer, Siemens and Sunovion). Some study authors report various other disclosures.


Young KA et al. Journal citation/abstract number. Chronic Obstr Pulm Dis. 2019;6(5):400-13.