Clinical Edge

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Pulmonary Rehabilitation and Depression in COPD

In patients with chronic obstructive pulmonary disease (COPD), pulmonary rehabilitation (PR) confers significant, clinically relevant benefits upon anxiety and depression symptoms, a new study found. The systematic review and meta-analysis was conducted according to PRISMA guidelines on randomized controlled trials comparing PR (≥4 weeks duration) to usual care. Researchers found:

  • 11 studies comprising 734 participants were included.
  • Compared with usual care, PR conferred significant benefits of a moderate magnitude for anxiety symptoms and large magnitude for depression symptoms.
  • The certainty of evidence for each outcome was moderate.


Gordon CS, Waller JW, Cook RM, et al. Effect of pulmonary rehabilitation on symptoms of anxiety and depression in chronic obstructive pulmonary disease: A systematic review and meta-analysis. [Published online ahead of print April 26, 2019]. Chest. doi:10.1016/j.chest.2019.04.009.