Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

New guideline conditionally recommends long-term home NIV for COPD patients

Key clinical point: Four conditional recommendations can help clinicians use long-term home non-invasive ventilation in chronic hypercapnic chronic obstructive pulmonary disease patients.

Major finding: Noninvasive ventilation may decrease dyspnea scores (standardized mean difference, –0.51; 95% confidence interval, –0.06 to 0.95) and increase health-related quality of life (SMD, 0.49; 95% CI, –0.01 to 0.98) in patients with chronic stable hypercapnic chronic obstructive pulmonary disease.

Study details: A series of recommendations developed by a European Respiratory Society task force of clinicians, methodologists, and experts in noninvasive ventilation and related fields.

Disclosures: The authors reported numerous conflicts of interest, including receiving grants and personal fees from various medical supply companies.


Ergan B et al. Eur Respir J. 2019 Aug 29. doi: 10.1183/13993003.01003-2019.