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Serum Testosterone and Estradiol Levels Associated With Current Asthma in Women

Key clinical point: Circulating sex hormones play a role in sex differences in asthma among adults and obesity modifies the effect of such hormones on asthma in women and men.

Major finding: Women whose serum testosterone levels were in the second and fourth quartiles had 30%-45% significantly lower odds of having current asthma than were those whose serum testosterone level was in the lowest quartile.

Study details: A cross-sectional study of data from 7,615 adults who participated in the 2013-2014 and 2015-2016 U.S. National Health and Nutrition Examination Survey.

Disclosures: One coauthor has received research materials from Merck and GlaxoSmithKline (inhaled steroids), as well as Pharmavite (vitamin D and placebo capsules), to provide medications free of cost to participants in National Institutes for Health–funded studies, unrelated to the current work. The other authors reported no conflicts of interest.


Han Y-Y et al. J Respir Crit Care Med. 2019 Sep 16. doi: 10.1164/rccm.201905-0996OC.