Clinical Edge

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Omalizumab shown to improve rhinosinusitis with polyps

Key clinical point: Omalizumab improved symptoms in people with chronic rhinosinusitis with nasal polyps.

Major finding: Sino-nasal outcome test scores improved 23.3 points in treated patients (P = .0001).

Study details: Subset analysis of 151 patients in the POLYP1 and POLYP2 Phase 2 trials of omalizumab.

Disclosures: Genentech sponsored the subset analysis. Hoffman-La Roche, Genentech’s parent company, is the sponsor of the POLYP1 and POLYP2 clinical trials. Dr. Corren is principal investigator of POLYP1 and disclosed financial relationships with Genentech.


Corren J et al. AAAAI Session 4608, Abstract 813.