Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Asthma-COPD Overlap in Low Income Countries

J Allergy Clin Immunol; ePub 2018 Oct 3; Morgan, et al

Asthma-COPD overlap (ACO) may be as prevalent and more severe in low- and middle-income countries (LMICs) than has been reported in high-income settings, a new study suggests. Researchers compiled cross-sectional data for 11,923 participants aged 35-92 years from 4 population-based studies in 12 settings. COPD was defined as post-bronchodilator FEV1/FVC below the lower limit of normal, asthma as wheeze or medication use in 12 months or self-reported physician diagnosis, and ACO has having both. Among the findings:

  • The prevalence of ACO was 3.8%.
  • The odds of having ACO were greater with household exposure to biomass fuel smoke (OR=1.48), smoking (OR=1.28), and having primary or less education (OR=1.35), when compared to non-obstructed individuals.
  • ACO was associated with severe breathing obstruction and severe spirometric deficits vs those with asthma or COPD alone.

Citation:

Morgan BW, Grigsby MR, Siddharthan T, et al. Epidemiology and risk factors of asthma-COPD in low- and middle-income countries. [Published online ahead of print October 3, 2018]. J Allergy Clin Immunol. doi:10.1016/j.jaci.2018.06.052.

This Week's Must Reads

Secondhand ENDS Aerosol Exposure & Asthma, CHEST; ePub 2018 Oct 22; Bayly, et al

FEV1 and FeNO Measurements & Prediction of Asthma, CHEST; ePub 2018 Oct 22; Fielding, et al

Predictors of ICS Response in Groups with Asthma , J Allergy Clin Immunol; ePub 2018 Oct 24; Levin, et al

Patient Inhaler Satisfaction & Asthma Control, Allergy Asthma Proc; ePub 2018 Oct 18; Plaza, et al

Asthma Medication Use Following Bariatric Surgery, Surg Endosc; ePub 2018 Oct 17; Guerron, et al

Must Reads in Asthma

Secondhand ENDS Aerosol Exposure & Asthma, CHEST; ePub 2018 Oct 22; Bayly, et al

FEV1 and FeNO Measurements & Prediction of Asthma, CHEST; ePub 2018 Oct 22; Fielding, et al

Predictors of ICS Response in Groups with Asthma , J Allergy Clin Immunol; ePub 2018 Oct 24; Levin, et al

Patient Inhaler Satisfaction & Asthma Control, Allergy Asthma Proc; ePub 2018 Oct 18; Plaza, et al

Asthma Medication Use Following Bariatric Surgery, Surg Endosc; ePub 2018 Oct 17; Guerron, et al