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Starting PCSK9 inhibitor in acute-phase ACS under study

Key clinical point: Starting a PCSK9 inhibitor plus a high-intensity statin soon after patients presented with acute-phase acute coronary syndrome proved to be a safe and well tolerated means of achieving massive LDL cholesterol lowering.

Major finding: Starting evolocumab plus high-intensity atorvastatin soon after patients presented with acute-phase acute coronary syndrome safely resulted in an LDL cholesterol reduction from 132 mg/dL to 31 mg/dL 8 weeks later.

Study details: This was a randomized trial of evolocumab or placebo injections plus high-intensity atorvastatin started during acute-phase acute coronary syndrome.

Disclosures: The EVOPACS study was sponsored by Amgen. The presenter reported receiving honoraria from Amgen and Sanofi.

Citation:

Koskinas KC. ESC 2019, Abstract 82.