From the Journals

Fruquintinib promising agent for advanced NSCLC

 

Key clinical point: Fruquintinib is a potential option for heavily pretreated patients with advanced non–small-cell lung cancer.

Major finding: Median progression free survival was 3.8 months (95% CI, 2.8 to 4.6 months) with fruquintinib versus 1.1 months (95% CI, 1.0 to 1.9 months) with placebo (stratified HR was 0.34 (95% CI,0.20 to 0.57; P less than .001).

Data source: Phase II multicenter, randomized, placebo controlled trial of 91 patients with advanced NSCLC.

Disclosures: Hutchison MediPharma supported the study. Dr. Lu and several coauthors report relationships with industry including Hutchison MediPharma.

Source: Lu S. et al. J Clin Oncol. 2018 Mar 12. doi: 10.1200/JCO.2017.76.7145.


 

FROM JOURNAL OF CLINICAL ONCOLOGY

Investigational agent fruquintinib holds promise as a third- or fourth-line treatment option for patients with advanced non–small-cell lung cancer (NSCLC), according to new findings published in the Journal of Clinical Oncology.

The median progression free survival (PFS) as evaluated by a blinded image central review committee and the study’s primary endpoint, was more than threefold higher than observed with placebo; 3.8 months (95% confidence interval, 2.8 to 4.6 months) with fruquintinib versus 1.1 months (95% CI, 1.0 to 1.9 months) with placebo (stratified HR was 0.34 (95% CI,0.20 to 0.57; P less than .001). PFS assessed by investigators was nearly identical.

Median overall survival, however, was numerically longer for patients in the placebo arm versus the fruquintinib arm (7.7 and 9.7 months in the fruquintinib and placebo groups; stratified HR, 0.70; 95% CI, 0.43 to 1.15; P = .152). The authors point out that overall survival is a secondary endpoint and the study was insufficiently powered to assess differences in overall survival.

“In patients with NSCLC who experienced treatment failure with two standard chemotherapies, fruquintinib may provide a clinically meaningful benefit, and further evidence of a statistically significant OS benefit of fruquintinib is expected from a phase 3 randomized study in this target population,” wrote Dr. Shun Lu of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Jiao Tong University, Shanghai, China, and colleagues.

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