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Type of Renal Dysfunction Affects Liver Cirrhosis Mortality Risk

Key clinical point: For non–status 1 patients with cirrhosis who are awaiting liver transplantation, type of renal dysfunction may be a key determinant of mortality risk.

Major finding: Patients with acute kidney injury and chronic kidney disease (AKI on CKD) had a 2.86-fold increased risk of death, compared with patients who had normal kidney function (subhazard ratio [SHR], 2.86).

Study details: A retrospective study involving 22,680 non–status 1 adults on the liver transplantation wait list.

Disclosures: The study was funded by a Paul B. Beeson Career Development Award and the National Institute of Diabetes and Digestive and Kidney Diseases. Dr. Verna disclosed relationships with Salix, Merck, and Gilead.

Citation:

Cullaro et al. Clin Gastroenterol Hepatol. 2019 Feb 1. doi: 10.1016/j.cgh.2019.01.043.