Key clinical point: Among patients with irritable bowel syndrome who tested negative for classic food allergies, most had an immediate disruption of the intestinal barrier in response to at least one food challenge.
Major finding: The most common trigger was wheat (61% of patients reacted), followed by yeast (20%), milk (9%), soy (7%), and egg white (4%). Eliminating the allergen for 3 months led to a 70% average improvement in IBS symptoms.
Study details: Confocal laser endomicroscopy with biopsy of 108 patients with irritable bowel syndrome.
Disclosures: Funders included the Rashid Hussein Charity Trust, the German Research Foundation, and the Leibniz Foundation. The researchers reported having no conflicts of interest.
Fritscher-Ravens A et al. Gastroenterology. 2019 May 14