Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

ACS Recommends CRC Screening at Age 45

CA Cancer J Clin; ePub 2018 May 30; Wolf, et al

The American Cancer Society (ACS) has issued new guidelines that recommends colorectal cancer (CRC) screening to begin at age 45 years for average-risk adults. Similar guidelines from other organizations recommended beginning screening at age 50 years. The ACS used an existing systematic evidence review of the CRC screening literature and microsimulation modeling analysis, including a new evaluation of the age to begin screening by race and sex and additional modeling that incorporates changes in US CRC incidence. Results from modeling analyses identified efficient and model-recommendable strategies that started screening at age 45 years. Among other ACS recommendations:

  • Regular CRC screening beginning at age 50 years is strongly recommended.
  • Regular screening is recommended through age 75 years for those at average risk who have a life expectancy of >10 years.
  • Clinicians should individualize the decision to screen for adults aged 76 to 85 years.
  • CRC screening should be discouraged among those aged ≥86 years.

Citation:

Wolf AMD, Fontham TH, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. [Published online ahead of print May 30, 2018]. CA Cancer J Clin. doi:10.3322/caac.21457.

This Week's Must Reads

USPSTF: Screening for Intimate Partner Violence, JAMA; 2018 Oct 23/30; US Preventive Services Task Force

High HbA1c Variability and Risk of MACE, Diabetes Care; ePub 2018 Oct 23; Ghouse, et al

Omega 3 Polyunsaturated Fatty Acids & Healthy Aging, BMJ; ePub 2018 Oct 17; Lai, Otto, et al

Gaps in HIV PrEP by Race and Ethnicity, MMWR; 2018 Oct 19; Huang, Zhu, et al

Kidney Damage Biomarkers & Incident CKD in BP Reduction, Ann Intern Med; ePub 2018 Oct 23; Zhang, et al

Must Reads in Clinical Guidelines

Screening for Syphilis Infection in Pregnant Women, JAMA; 2018 Sep 4; US Preventive Services Task Force

Treatment Intensification Guidelines for T2D , Ann Intern Med; ePub 2018 Sep 4; Roglic, et al

Low-Calorie Sweetened Beverages & Cardiometabolic Health, Circulation; ePub 2018 Jul 30; Johnson, et al

Antiretroviral Drugs for Management of HIV, JAMA; 2018 Jul 24/31; Saag, Benson, et al

ACC/AHA Guideline Impact on Prevalence of Hypertension, BMJ; ePub 2018 Jul 11; Khera, Lu, et al