Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Obesity Associated With Adverse CV Outcomes?

JAMA Netw Open; 2018 Nov 16; Riaz, et al

Obesity is associated with type 2 diabetes (T2D) and coronary artery disease (CAD), but not with stroke, according to a systematic review and meta-analysis of nearly 1 million participants. Studies that used mendelian randomization methods to assess the association between any measure of obesity and the incidence of cardiovascular (CV) events and those that reported odds ratios (ORs) with 95% CIs estimated using an instrumental variable method were included. 5 studies were included in the final analysis. Researchers found:

  • Of 4,660 potentially relevant articles, 2,511 titles were screened; 7 were included in the systematic review, and 5 with 881,692 participants were eligible for inclusion in the meta-analysis.
  • Obesity was significantly associated with an increased risk of T2D (OR, 1.67) and CAD (OR, 1.20).
  • However, no association between obesity and stroke was found (OR, 1.02).


Riaz H, Khan MS, Siddiqi TJ, et al. Association between obesity and cardiovascular outcomes. A systematic review and meta-analysis of mendelian randomization studies. JAMA Netw Open. 2018;1(7):e183788. doi:10.1001/jamanetworkopen.2018.3788.

This Week's Must Reads

AHA Statement: CV Risk Reduction in Pediatrics, Circulation; ePub 2019 Feb 25; de Ferranti, et al

Epicutaneous Immunotherapy in Peanut Allergy, JAMA; ePub 2019 Feb 22; Fleischer, et al

Opioid-Related Mortality in US by Opioid Type, JAMA Netw Open; 2019 Feb 22; Kiang, et al

Insulin Management in Patients with T2D, Lancet; ePub 2019 Feb 22; Bergenstal, et al

Vaccination for Prevention of Herpes Zoster, Ann Intern Med; ePub 2019 Feb 19; Prosser, et al

Must Reads in Cardiology

AHA Statement: CV Risk Reduction in Pediatrics, Circulation; ePub 2019 Feb 25; de Ferranti, et al

Sedentary Behaviors & CVD Risk in Older Women, Circulation; 2019 Feb 19; Bellettiere, et al

Intensive BP Control & Risk of Probable Dementia, JAMA; 2019 Jan 28; SPRINT Mind Investigators

Are Automated Office BP Readings More Accurate?, JAMA Intern Med; ePub 2019 Feb 4; Roerecke, et al

BMI Measurements and Intensive BP Management , Am J Med; ePub 2019 Feb 2; Oxlund, et al