Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Obesity Associated With Adverse CV Outcomes?

JAMA Netw Open; 2018 Nov 16; Riaz, et al

Obesity is associated with type 2 diabetes (T2D) and coronary artery disease (CAD), but not with stroke, according to a systematic review and meta-analysis of nearly 1 million participants. Studies that used mendelian randomization methods to assess the association between any measure of obesity and the incidence of cardiovascular (CV) events and those that reported odds ratios (ORs) with 95% CIs estimated using an instrumental variable method were included. 5 studies were included in the final analysis. Researchers found:

  • Of 4,660 potentially relevant articles, 2,511 titles were screened; 7 were included in the systematic review, and 5 with 881,692 participants were eligible for inclusion in the meta-analysis.
  • Obesity was significantly associated with an increased risk of T2D (OR, 1.67) and CAD (OR, 1.20).
  • However, no association between obesity and stroke was found (OR, 1.02).

Citation:

Riaz H, Khan MS, Siddiqi TJ, et al. Association between obesity and cardiovascular outcomes. A systematic review and meta-analysis of mendelian randomization studies. JAMA Netw Open. 2018;1(7):e183788. doi:10.1001/jamanetworkopen.2018.3788.

This Week's Must Reads

CVD Events Prevented with New AHA BP Guideline, Circulation; ePub 2018 Nov 19; Bress, et al

USPSTF: Interventions to Prevent Child Maltreatment, JAMA; 2018 Nov 27; US Preventive Services Task Force

Team-Based Primary Care in Chronically Ill Patients, JAMA Intern Med; ePub 2018 Nov 26; Meyers, et al

Rotating Night Shift Work & Risk of T2D, BMJ; ePub 2018 Nov 21; Shan, Li, et al

PUFAs for Primary & Secondary CVD Prevention, Cochrane Library; ePub 2018 Nov 27; Abdelhamid, et al

Must Reads in Cardiology

CVD Events Prevented with New AHA BP Guideline, Circulation; ePub 2018 Nov 19; Bress, et al

PUFAs for Primary & Secondary CVD Prevention, Cochrane Library; ePub 2018 Nov 27; Abdelhamid, et al

Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al

Cholesterol Guidelines Stress Lifetime Approach, Circulation; ePub 2018 Nov 10; Grundy, et al

Does Vitamin D Reduce Cancer & CVD Risk?, N Engl J Med; ePub 2018 Nov 10; Manson, et al