A truly deadly quartet: Obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia.
The best available treatment is to control one's weight, exercise regularly, stop smoking, and eat a healthy diet.
VIJAY NAMBI, MD
Department of Internal Medicine, The Cleveland Clinic
BYRON J. HOOGWERF, MD
Director, Internal Medicine Residence Program, Department of Endocrinology, The Cleveland Clinic
DENNIS L. SPRECHER, MD
Head, Section of Preventive Cardiology and Cardiac Rehabilitation, Department of Cardiovascular Medicine, The Cleveland Clinic
ADDRESS: Dennis L. Sprecher, MD, Department of Cardiology, C51, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail firstname.lastname@example.org.
The National Cholesterol Education Program recognizes the importance of the metabolic syndrome and has published guidelines for its diagnosis. Weight loss, physical activity, and treatment of the individual risk factors constitute the main strategies for treatment. For now, the goals and methods of treating hypertension and dyslipidemia are the same in people with the metabolic syndrome as in the general population. Thiazolidinedione drugs increase insulin sensitivity, but their use in the metabolic syndrome is only speculative at present. We recommend they be used only as indicated to treat diabetes mellitus.