Preglomerular and postglomerular blood flow: relationship to kidney disease and treatment
Sharon R. Inman, PhD
Ben H. Brouhard, MD
Nicholas T. Stowe, PhDAddress reprint requests to N.T.S., Director, Nephro-Urologic Research Laboratory, FF40, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.
In the kidney, the afferent and efferent arterioles normally constrict or dilate in response to changes in systemic blood pressure to maintain glomerular filtration while protecting the glomerulus from excessive pressure. In diabetes mellitus and hypertension, the two most common causes of kidney failure, sustained hypertension within the glomerulus damages the glomerular membrane and eventually results in loss of kidney function.SUMMARY
Techniques developed in the last 10 years allow direct study of the glomerulus and the glomerular circulation. In both diabetes and hypertension, the afferent vessels may dilate, resulting in excessive pressure in the glomerulus. Calcium antagonists, angiotensin-converting enzyme inhibitors, and cyclosporine have direct effects on the preglomerular and postglomerular vessels, and the afferent and efferent arterioles may respond differently to the same agent.CONCLUSIONS
Techniques for studying afferent and efferent arteriolar changes and glomerular filtration rate may provide important insights into the actions of drugs and into renal diseases. Clinicians are beginning to be able to select drugs that have desired effects on the renal microcirculation.