Therapeutic Typhoid Shock


Nonspecific typhoid shock provides a safe and important method for the production of artificial fever. We have had no unfavorable results and no deaths following its use in several hundred patients. Furthermore, we have found that the fever and chills caused by the intravenous administration of typhoid vaccine have produced satisfactory improvement in properly selected cases. The glands and other cellular tissues of the body participate actively in the febrile reaction which may serve not only to place the pathogenic bacteria in an environment that is unfavorable to viability and reproduction, but the reactions of the cells may serve to enhance the formation of antibodies as well. Some authorities doubt that this twofold reaction can be produced by passive fever induced in the heat cabinet. Likewise, many syphilog-raphers declare that, in the treatment of general paresis, the end results are better after a course of chills induced by malaria than after treatment in the heat cabinet even though, in the latter instance, the temperature may be maintained at 105° to 106.5° F. for as long as six to eight hours. We recognize, too, that in a disease such as erythema nodosum the lesions may disappear with great rapidity when milk protein is given intramuscularly. In this instance, no fever, no chills, and no noticeable general reaction or discomfort occur. This nonspecific effect of protein appears to be active in the reaction to typhoid shock.

There are certain objections to heat therapy produced by use of a cabinet, especially because it. . .



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