Fixed drug eruption from pamabrom
Susan Nedorost, MD
James S. Taylor, MDAddress reprint requests to J.S.T., Department of Dermatology, The Cleveland Clinic Foundation, One Clinic Center, 9500 Euclid Avenue, Cleveland Ohio 44195.
Charles Camisa, MD
Kenneth J. Tomecki, MD
Thomas Helm, MD
William J. Durkin
A young woman presented with recurrent skin lesions that were predominantly perioral. Fixed drug reaction was diagnosed based on her history of intermittent ingestion of Pamprin, a common menstrual symptom reliever, and characteristic erythematous, pigmented, edematous patches. After oral challenge with two of the three ingredients in Pamprin, a diagnosis of fixed drug reaction to pamabrom was made. Pamabrom is a mild diuretic present in several over-the-counter and prescription menstrual symptom relievers. This is the first reported case of fixed drug reaction to pamabrom.