Intractable seizure disorders of childhood1
A. David Rothner, M.D.
Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland OH 44106
The evaluation of the child with intractable seizures is reviewed. Important in this diagnosis are a review of the history to classify seizures and rule out nonepileptiform conditions; a review of the general physical and neurological examinations to rule out any previously undiagnosed conditions; repeating laboratory studies to make sure no etiologies have been Undiscovered; and the use of multiple therapies, including combinations of antiepileptic drugs, the ketogenic diet, and seizure surgery. Infantile spasms, myoclonic seizures, and complex partial seizures have the most unfavorable prognoses.