Intractable seizure disorders of childhood1

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The evaluation of the child with intractable seizures is reviewed. Important in this diagnosis are a review of the history to classify seizures and rule out nonepileptiform conditions; a review of the general physical and neurological examinations to rule out any previously undiagnosed conditions; repeating laboratory studies to make sure no etiologies have been Undiscovered; and the use of multiple therapies, including combinations of antiepileptic drugs, the ketogenic diet, and seizure surgery. Infantile spasms, myoclonic seizures, and complex partial seizures have the most unfavorable prognoses.



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