Combined desmopressin (DDAVP) and chlorpropamide therapy for diabetes insipidus with absent thirst1

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A patient with neurogenic diabetes insipidus and defective thirst regulation due to a craniopharyngioma is described who responded to a combination of desmopressin (DDAVP) and chlorpropamide with improved thirst regulation and decreased urine output. When DDAVP was discontinued he became hypernatremic. This patient required both DDAVP and chlorpropamide to maintain normonatremia.



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