Prognosis for adolescents with Hodgkin’s disease1

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From 1972 to 1983, 68 adolescents, aged 12 to 20 years (median 17.6 years), with Hodgkin’s disease received treatment at the Cleveland Clinic. Although the overall male:female ratio was 1.2:1.0, male predominance was greater in younger adolescents. The histopathologic distribution was overwhelmingly nodular sclerosing (69%), but 24% were mixed cellularity, and 7% were lymphocyte-predominant. There was no statistical relationship between histopathology and survival. All patients were pathologically staged (PS): PS-I = 11 patients, PS-II = 26 patients, PS-III = 17 patients, and PS-IV = 14 patients. The overall five-year survival rate was 83%, and there was no significant difference between pathological stage and chance of survival. Treatment programs had been based on pathological staging, usually irradiation therapy for stages I and II, combination chemotherapy for stage IV, and both modalities combined for stage III. This therapy has resulted in an excellent five-year survival rate for these adolescents.



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