Influence of HLA AB and DR antigen matching in transfused cadaver renal transplant patients1
Sergio J. Rybka, M.D.
Andrew C. Novick, M.D.
William E. Braun, M.D.
Donald Steinmuller, M.D.
This is a retrospective analysis of the results of HLA AB and DR antigen matching in 56 transfused cadaver transplant patients. Maintenance immunosuppression in these patients comprised Imuran, prednisone, and an initial two-week course of ALG. Matching for HLA AB or DR antigens alone failed to yield subgroups with significant differences in graft outcome. However, with combined HLA AB and DR matching criteria, a subgroup of 0 DR, < 2 AB matched recipients was identified with significantly diminished graft survival. These preliminary data support a role for tissue matching in cadaver transplantation and suggest that combined matching for HLA AB and DR antigens may be more useful than matching for either alone.