Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy
C. William Hanke, M.D.
Wilma F. Bergfeld, M.D.
Marcelle N. Guirguis, M.D.
L. James Lewis, Ph.D.
One of the four major components of Graves’ disease, pretibial myxedema (PTM), occurs in approximately 0.5% to 4.3% of patients with ophthalmic goiter and is often seen following treatment of the goiter. An advanced case of elephantiasic PTM is reported.