Treatment of Undulant Fever by Artificial Fever Therapy

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Despite the fact that undulant fever is now recognized as a widespread and fairly prevalent disease, methods for its treatment are still somewhat uncertain. Brucellosis has in the past been treated chiefly by chemotherapy, vaccine, and serum therapy. The vaccines used have generally been of two types, specific Brucella vaccine or a fever producing vaccine, such as typhoid and paratyphoid A and B. From a review of many cases1 reported during the past decade, it appears that the results obtained by the administration of a fever producing vaccine have been most gratifying. It was observed that the undulant fever disappeared more often in those patients in whom a febrile reaction had been obtained.

It has been demonstrated by many workers that fever induced by physical means is of value in any condition for which malarial, typhoid, or protein injection therapy is indicated. A recent report2 indicated favorable results in four patients treated by artificial fever. In the following case, the patient responded very satisfactorily.

Report of Case

The patient, a married farmer, 54 years of age, was admitted to the Cleveland Clinic on April 30, 1937. His complaint was of pain in the scrotum with marked edema, pain in the left hip, right shoulder and the hands, weakness, and periods of diaphoresis.

Past history: About a year previous to examination—in April, 1936—the patient had pains in various joints. These were similar to those he was experiencing at the time of our examination and he stated that such pains had. . .



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