Article

Successful Use of Prontosil in a Severe Case of Streptococcus Septicemia Following Cystoscopy and Peri-Urethral Abscess

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Abstract

Several months ago there was introduced into our therapeutic armamentarium a new chemical agent said to be specific for an organism which has always presented a problem to the physician—the Streptococcus. The trade name of this substance—disodium 4-sulphamidophnyl-2-azo-7-acetylamino- 1-hydroxynaphthalene 3, 6-disulphonate— is Prontosil. Convincing clinical as well as pharmacologic evidence has thoroughly established its efficacy in Germany and England. In England, its value in infections due to Streptococcus haemolyticus has been particularly stressed and even in cases of well developed blood stream infections, as in puerperal septicemia, recovery has frequently occurred and the mortality rate has been greatly reduced. It has been shown to be effective in the treatment of severe infections due to other forms of Streptococci, and it has been reported to be specific for the Gonococcus.

The following is a striking demonstration of the promptness of action and rapid reduction of temperature following the administration of Prontosil. Perhaps an even more striking result would have been obtained had the dosage been adequate from the beginning.

Report of Case

The patient was a young man, 20 years of age, who was brought to the Cleveland Clinic Hospital in an ambulance. He was admitted on the general surgical service with the following complaints: chills and fever and abscess at the base of the penis which had been present for two weeks and pain over the left kidney during the preceding four months.

Past history revealed that, at the age of 4 years, he had had scarlet fever. . .


 

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