The Friedman Test Technique and Interpretation

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The Friedman test1 was devised principally to aid in the early diagnosis of pregnancy. The test can also be used for diagnostic purposes in a number of other conditions in which there may be reason to suspect an excess of gonadotropic hormone in the urine.2 This is especially true in conditions of pituitary dysfunction due to a primary pituitary hyperactivity or secondary pituitary hyperactivity resulting from hypogonadism including the menopause and where there is chorionic epithelium in the body. In cases of pituitary tumor the test is useful not only in estimating the degree of hyperactivity of the gland, but also in checking the decrease in pituitary activity once roentgenotherapy has been started. The use of Friedman tests at frequent intervals when patients are being treated with roentgenotherapy for pituitary tumor often indicates a reactivation of the glandular tumor after a period of quiescence. The degree of the positive reaction, found so often at the onset of the menopause, may be of considerable value in governing ovarian therapy in order to relieve the symptoms due to the secondary pituitary hyperactivity.

Although the test is primarily qualitative, with care it can be used in a roughly quantitative manner. In order to accomplish this, certain features of the reaction which are herein described require special attention.

The Friedman test is done at the Cleveland Clinic according to directions received in a personal communication from Dr. Maurice Friedman in 1931. Slight modifications having to do with the collection of the urine and not. . .



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