Duration of effect of single daily doses of reserpine and hydroflumethiazide evaluated by noninvasive technology in hypertensive patients

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Reserpine’s long-lasting antihypertensive action is advantageous in the treatment of the chronically ill who can take medication only once a day. To evaluate the 24-hour effect on blood pressure of single doses of reserpine (0.125 mg) and hydroflumethiazide (50 mg) combined in one tablet (Salutensin), an ambulatory blood pressure monitor was used that automatically measures and records blood pressure every 7.5 minutes for 26 hours.

Methods and materials

Data are derived from 21 patients with primary (essential) hypertension who completed the protocol. There were 15 men and 6 women; 12 were black and 9 white. Ages ranged from 32 to 74 years (mean, 54 years). Hypertensive complications were not a reason for exclusion from the study, but only 3 patients had evidence of target organ disease. One had a history of myocardial infarction, one had azotemia (serum creatinine, ≥1.5 mg/dl), and one had both azotemia and angina pectoris. None had accelerated hypertension (Keith-Wagener-Barker groups III and IV).

The plan and purpose of the investigation were explained to the patients, and each signed an informed consent form before being included in the study.

All subjects had a history of hypertension; 16 were taking antihypertensive medication when selected, but discontinued therapy at least one month before entering the study.

Patients were seen in the office at two-week intervals throughout the study. Blood pressure was measured in the right arm with a standard mercury manometer; the 5th Korotkoff phase was used as the diastolic blood pressure. At each visit, after an initial 10-minute . . .



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